Clostridium novyi-T BioVector NTCC质粒载体菌种细胞基因保藏中心

Clostridium novyi-T BioVector NTCC质粒载体菌种细胞基因保藏中心 The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas.C. novyi is ubiquitously encountered in the soil and feces of the environment from where it can infect animals and humans. 16 Although rare, human infections of wild-type C. novyi leading to gas gangrene are often fatal particularly after traumatic wounds or illicit drug use due to the secretion of the lethal α-toxin, 30 which was deleted in the therapeutic strain. C. novyi-NT is a highly motile bacterium that is exquisitely sensitive to oxygen; vegetative forms cannot survive in oxygen while bacterial spores can only germinate in hypoxic conditions. [Supplier来源] http://www.biovector.net