LCC2人乳腺癌Tamoxifen耐药株 BioVector NTCC质粒载体菌种细胞基因保藏中心

LCC2人乳腺癌Tamoxifen耐药株 BioVector NTCC质粒载体菌种细胞基因保藏中心 MCF7/LCC2 cell line Cat No.: NTCC595403 Cell line name MCF7/LCC2 Synonyms MCF-7/LCC-2; MCF-7/LCC2; MCF-7-LCC2; LCC2 Comments Selected for resistance to: Afimoxifene (4-hydroxytamoxifen; 4-OH TAM). Omics: Proteome analysis. Disease Invasive ductal carcinoma, not otherwise specified Derived from metastatic site: Pleural effusion. Species of origin Homo sapiens (Human) Hierarchy Parent: (MCF7/LCC1) Sex of cell Female Category Cancer cell line Publications PubMed=8324732 Brunner N., Frandsen T.L., Holst-Hansen C., Bei M., Thompson E.W., Wakeling A.E., Lippman M.E., Clarke R. MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780. Cancer Res. 53:3229-3232(1993) The development of resistance to the antiestrogen tamoxifen occurs in a high percentage of initially responsive patients. We have developed a new model in which to investigate acquired resistance to triphenylethylenes. A stepwise in vitro selection of the hormone-independent human breast cancer variant MCF-7/LCC1 against 4-hydroxytamoxifen produced a stable resistant population designated MCF7/LCC2. MCF7/LCC2 cells retain levels of estrogen receptor expression comparable to the parental MCF7/LCC1 and MCF-7 cells. Progesterone receptor expression remains estrogen inducible in MCF7/LCC2 cells, although to levels significantly lower than observed in MCF-7 and MCF7/LCC1 cells. MCF7/LCC2 cells form tumors in ovariectomized nude mice without estrogen supplementation, and these tumors are tamoxifen resistant but can be estrogen stimulated. Significantly, MCF7/LCC2 cells have retained sensitivity to the steroidal antiestrogen ICI 182,780. These data suggest that some breast cancer patients who acquire resistance to tamoxifen may not develop cross-resistance to treatment with steroidal antiestrogens. BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心www.biovector.net [Supplier来源] http://www.biovector.net