pCMV-Med23-myc BioVector NTCC质粒载体菌种细胞基因保藏中心

pCMV-Med23-myc BioVector NTCC质粒载体菌种细胞基因保藏中心 MED23 -Human mediator complex subunit 23 (MED23), transcript variant 2. RefSeq Explanation: NM_015979.2 NM_015979.3 , NP_057063 Synonyms: ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR-2; SUR2 RefSeq Size: 4616 RefSeq ORF: 4098 LocusID: 9439 Cytogenetic: 6q23.2 Gene Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012] [Supplier来源] http://www.biovector.net