E. Coli Nissle 1917.（EcN）菌株 BioVector NTCC中国质粒载体菌种细胞基因保藏中心

E. Coli Nissle 1917.（EcN）菌株 BioVector NTCC中国质粒载体菌种细胞基因保藏中心 The E. coli strain Nissle 1917 (EcN) disposes of a number of properties which are important to its survival, colonization ability, and persistence in the intestinal ecosystem, and to its therapeutic efficacy. • Mobility due to type H1-flagella • Ability to colonize due to specific interaction of its ¬flagellae with the mucin layer • Ability to form biofilms due to F1A-, F1C- and Curli-fimbriae • Antagonistic activity directed against foreign microbes due to antimicrobial microcins • Vitality and resilience (“biological fitness”) due to ¬multiple iron uptake systems • Immunomodulatory effects due to strain-specific ¬surface structures (special LPS = lipopolysaccharide) and synthesis of immunomodulatory signal substances • Anti-inflammatory effects • Stabilizing effect on the barrier function of the intestinal mucosa References 1) Blum G et al. Properties of Escherichia coli strains of serotype O 6. Infection 1995; 23: 234–236. 2) Sonnenborn U, Schulze J. The non-pathogenic Escherichia coli strain Nissle 1917 – features of a versatile probiotic. Microbial Ecol Health Dis 2009; 21: 122–158. 3) Schiemann M et al. 125 Jahre E. coli – Bedeutung in Forschung und Medizin. Alfred-Nissle¬-Gesellschaft (Hrsg.) Hagen, ISBN 3-9811198-4-3, 2010. [Supplier来源] http://www.biovector.net