MDA-PATC50 BioVector®人胰腺导管腺癌细胞Human Pancreatic Ductal Adenocarcinoma Cell Line

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BioVector® MDA-PATC50 人胰腺导管腺癌细胞 (Human Pancreatic Ductal Adenocarcinoma Cell Line)

BioVector® MDA-PATC50 (人胰腺导管腺癌细胞)

物种：人 (Homo sapiens)
细胞类型：胰腺导管腺癌 (PDAC)，中度分化，IIB期
组织来源：取材自一名 60 岁高加索女性患者的胰腺原位肿瘤，通过 NOD/SCID 小鼠异种移植瘤 (PDX) 模型建立。
生长特性：贴壁生长。
倍增时间：约 99 小时（较慢）。
分子特征：
- 关键突变：携带 KRAS (p.G12R) 突变（c.34G>C）。
- 基因缺失：存在 SMAD4 纯合缺失。
- 表型标记：表现出间充质特征，Cytokeratin-19 (CK19) 和 Vimentin 表达增加。
培养基推荐： 90% RPMI 1640 (ATCC 30-2001) + 10% 胎牛血清 (FBS)。
主要应用：胰腺癌生物学研究、KRAS 突变靶向药物筛选、SMAD4 缺失相关的信号通路研究。

BioVector® MDA-PATC50 (Human Pancreatic Ductal Adenocarcinoma Cell Line)

Species: Human (Homo sapiens)
Cell Type: Pancreatic Ductal Adenocarcinoma (PDAC), moderately differentiated, Stage IIB.
Origin: Established from a pancreatic in situ tumor of a 60-year-old Caucasian female via NOD/SCID murine xenograft (PDX).
Growth Properties: Adherent.
Doubling Time: Approximately 99 hours.
Molecular Characteristics:
- Key Mutation: Carries KRAS (p.G12R) mutation (c.34G>C).
- Gene Deletion: Features homozygous deletion of SMAD4.
- Markers: Exhibits mesenchymal-like features with increased expression of CK19 and Vimentin.
Culture Medium: 90% RPMI 1640 (ATCC 30-2001) + 10% Fetal Bovine Serum (FBS).
Applications: Research in pancreatic cancer biology, drug screening targeting KRAS mutant pathways, and studies on SMAD4-deficient signaling.