LU2511大细胞未分化肺癌异种移植（PDX）模型 BioVector NTCC保藏中心

BioVector® NTCC® LU2511大细胞未分化肺癌异种移植（PDX）模型

BioVector® LU2511指的是一个患者来源的异种移植（PDX）模型，而非传统的体外细胞系。这是一个在小鼠体内生长的肺癌模型。
LU2511 PDX模型的主要特点
来源：该模型源自一位49岁女性患者的大细胞未分化肺癌。
组织来源：样本取自患者的肺部。
组织病理学：对肿瘤组织的病理学分析证实其为大细胞未分化癌。肿瘤块的描述为7厘米 x 6厘米 x 6厘米。
免疫组织化学（IHC）：肿瘤的标志物染色结果显示CK和EMA呈阳性，而Vim和CK7呈阴性。同时，Syn呈阳性，CD56呈阴性。P63染色较弱。
肿瘤生长：PDX模型在Balb/c裸鼠体内生长，用于体内研究这类肺癌的生物学特征。
研究应用
转化研究：LU2511模型用于在活体系统中研究人类肺癌的生长和进展。
药物筛选：用于测试新的癌症治疗方法，特别是针对大细胞未分化癌的治疗。
肿瘤微环境研究：该模型可以在体内研究复杂的肿瘤微环境和转移。
什么是PDX模型？
PDX模型是通过将患者的人类肿瘤组织直接植入免疫缺陷小鼠体内而创建的。与在实验室培养皿中体外生长的细胞系不同，PDX模型保留了原始肿瘤的大部分特征，包括其遗传异质性、组织病理学和肿瘤微环境。这使得PDX模型成为临床前癌症研究的重要工具，因为它们比传统的细胞系更能准确地模拟人类癌症。
BioVector® LU2511 refers to a patient-derived xenograft (PDX) model, not a traditional in vitro cell line. It is a lung cancer model that is grown in mice.
Key characteristics of the LU2511 PDX model
Origin: The model was derived from a 49-year-old female patient with a large cell undifferentiated lung carcinoma.
Source tissue: The sample was taken from the patient's lung.
Histopathology: Pathological analysis of the tumor tissue confirmed it to be a large cell undifferentiated carcinoma. The tumor mass was described as being 7cm x 6cm x 6cm.
Immunohistochemistry (IHC): The tumor was positive for the markers CK and EMA, and negative for Vim and CK7. It was also positive for Syn and negative for CD56. P63 staining was weak.
Tumor growth: The PDX model is grown in Balb/c nu mice and is used to study the biological features of this type of lung cancer in vivo.
Research applications
Translational research: The LU2511 model is used to investigate the growth and progression of human lung cancer in a living system.
Drug screening: It is used to test the efficacy of new cancer treatments, especially those targeting large cell undifferentiated carcinoma.
Tumor microenvironment studies: The model allows for the study of the complex tumor microenvironment and metastasis in vivo.
What is a PDX model?
A PDX model is created by implanting human tumor tissue from a patient directly into an immunodeficient mouse. Unlike a cell line, which is grown in vitro in a lab dish, the PDX model maintains much of the original tumor's characteristics, including its genetic heterogeneity, histopathology, and tumor microenvironment. This makes PDX models a valuable tool for preclinical cancer research, as they more accurately mimic human cancer than traditional cell lines.

Supplier来源:BioVector NTCC Inc.
Email: biovector@163.com
Website网址: http://www.biovector.net