MOS-J小鼠自发性软骨母细胞性骨肉瘤细胞株 BioVector NTCC保藏中心

BioVector® NTCC® MOS-J小鼠自发性软骨母细胞性骨肉瘤细胞株

The NTCC® MOS-J cell line is a mouse osteosarcoma cell line, derived from a spontaneously occurring chondroblastic osteosarcoma. It is an important research model for studying bone cancer and bone biology.
Key characteristics
Origin: The cell line was established in 2002 from a spontaneously occurring chondroblastic osteosarcoma in the distal right femur of a female C57BL/6J mouse.
Osteogenic properties: MOS-J cells exhibit key osteoblastic features in vitro, including high alkaline phosphatase (ALP) activity and the ability to form calcified foci.
Promotes osteoclast development: These cells also promote the differentiation of normal bone marrow cells into osteoclasts, a process crucial for bone remodeling.
Tumorigenicity: When injected into syngeneic hosts (mice of the same genetic strain), MOS-J cells form solid tumors that mimic the characteristics of endochondral bone development. The tumors can invade and destroy existing bone.
Applications:
Osteosarcoma research: It serves as a valuable model for studying human osteosarcoma, a common type of bone cancer.
Drug development: MOS-J cells have been used to evaluate chemotherapy drug responses.
Bone biology: Due to its osteoblastic characteristics and ability to promote osteoclast development, it is useful for studying various aspects of bone biology.
Resources and references
Cellosaurus: The Cellosaurus database provides detailed information on the MOS-J cell line under the accession number CVCL_0J56.
Publications: The original paper describing the establishment and characterization of the cell line was published in In Vivo in 2002.
Animal models: MOS-J cells are used to create syngeneic mouse models of osteosarcoma, including jaw osteosarcoma (JOS) models.

NTCC® MOS-J细胞系是一种小鼠骨肉瘤细胞系，源自自发性软骨母细胞性骨肉瘤。它是研究骨癌和骨生物学的重要研究模型。
主要特点
来源：该细胞系于2002年建立，源自一只雌性C57BL/6J小鼠右股骨远端自发性发生的软骨母细胞性骨肉瘤。
成骨特性：MOS-J细胞在体外表现出关键的成骨细胞特征，包括高碱性磷酸酶（ALP）活性和形成钙化灶的能力。
促进破骨细胞分化：这些细胞还能促进正常骨髓细胞分化为破骨细胞，这一过程对骨重塑至关重要。
致瘤性：当MOS-J细胞被注射到同基因宿主（同一遗传品系的小鼠）体内时，会形成实体瘤，其特征类似于软骨内骨骼发育。这些肿瘤能够侵袭和破坏已有的骨骼。
应用：
骨肉瘤研究：作为研究人类骨肉瘤（一种常见的骨癌）的宝贵模型。
药物开发：MOS-J细胞已用于评估化疗药物的反应。
骨生物学：因其成骨细胞特性和促进破骨细胞发育的能力，对研究骨骼生物学的各个方面都非常有用。
资源与参考
Cellosaurus数据库：Cellosaurus数据库提供了MOS-J细胞系的详细信息，其登录号为CVCL_0J56。
相关出版物：描述该细胞系建立和表征的原始论文于2002年发表在《体外（In Vivo）》期刊上。
动物模型：MOS-J细胞被用于构建同基因小鼠骨肉瘤模型，包括颌骨骨肉瘤（JOS）模型。

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