NuTu-19-luc卵巢腺癌细胞荧光素酶表达细胞株-BioVector NTCC典型培养物保藏中心

• Source: The parental NuTu-19 line was developed from a spontaneous ovarian surface epithelial cell tumor in a female Fischer 344 rat.

• Cell Type: Rat ovarian adenocarcinoma epithelial cell line.

• Luciferase Expression: The NuTu-19-luc line has been transduced to constitutively express the firefly luciferase gene. This genetic modification allows the cells to produce a bioluminescent signal, which can be detected with specialized imaging equipment when the substrate luciferin is added.

• In vivo cancer research: The cells can be injected into laboratory animals (e.g., rats) to create a tumor model. The resulting tumors can then be monitored non-invasively and in real-time using bioluminescence imaging (BLI).

• Metastasis tracking: The bioluminescent signal allows researchers to quantitatively track tumor growth, progression, and metastasis within a living animal.

• Drug screening and therapeutic efficacy: The response of tumors to various treatments can be quantitatively assessed over time by measuring changes in the luciferase signal. This provides a high-throughput method for evaluating the efficacy of new cancer therapies.

• Oncology studies: More broadly, the cell line is a tool for studying tumorigenesis, apoptosis, and other biological processes in the context of ovarian cancer.

• 来源: 亲代 NuTu-19 细胞系来源于雌性 Fischer 344 大鼠的自发性卵巢表面上皮细胞肿瘤。

• 细胞类型: 大鼠卵巢腺癌上皮细胞系。

• 荧光素酶表达: NuTu-19-luc 细胞系经过转染，可以组成型地表达萤火虫荧光素酶基因。这种基因改造使细胞能够产生生物发光信号，当加入底物荧光素后，可以通过专门的成像设备进行检测。

• 体内癌症研究: 研究人员可以将这种细胞注入实验动物（如大鼠）体内，建立肿瘤模型。随后，利用生物发光成像（BLI）技术，可以对形成的肿瘤进行实时、无创的监测。

• 转移追踪: 生物发光信号使研究人员能够在活体动物体内定量追踪肿瘤的生长、进展和转移情况。

• 药物筛选和疗效评估: 通过测量荧光素酶信号随时间的变化，可以定量评估肿瘤对各种治疗的反应。这为评估新癌症疗法的有效性提供了一种高通量的方法。

• 肿瘤学研究: 更广泛地说，该细胞系是研究卵巢癌发生、凋亡和其他生物过程的有用工具

BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心

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