NTCC™小鼠巨细胞病毒（MCMV，Murine Cytomegalovirus）BioVector NTCC典型培养物保藏中心

NTCC™小鼠巨细胞病毒（MCMV，Murine Cytomegalovirus），它是一种属于疱疹病毒科β亚科的DNA病毒，是小鼠的天然病原体。

主要特点

• 分类: MCMV 属于疱疹病毒群，是一种有包膜的双链DNA病毒。它的基因组结构和基因表达模式与人巨细胞病毒（HCMV）有许多相似之处。

• 宿主特异性: MCMV 具有严格的宿主特异性，仅能感染小鼠。尽管它能在体外感染大鼠细胞，但在体内并不会在大鼠身上复制。

• 感染途径: 病毒可通过唾液、尿液、眼泪等体液传播。在自然感染中，病毒主要定位于小鼠的唾液腺并持续存在。

• 临床症状: 在免疫功能正常的小鼠中，MCMV 的自然感染通常没有明显的临床症状。但在某些特定品系或免疫缺陷的小鼠中，可能会引起中枢神经系统或心肌病变。

研究应用

由于人巨细胞病毒（HCMV）具有严格的物种特异性，无法直接感染小鼠，因此 MCMV 感染小鼠的模型成为了研究 HCMV 相关疾病和发病机制的重要替代方案。研究人员利用这个模型来：

• 研究免疫反应: 探索宿主对巨细胞病毒感染的先天性和适应性免疫应答机制。

• 疫苗和抗病毒药物开发: 用于评估疫苗候选物和新型抗病毒药物的有效性。

• 研究病毒潜伏期和复活: 巨细胞病毒感染后会进入潜伏期，并在特定条件下重新激活。MCMV 模型是研究这一复杂过程的理想工具。

BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心

BioVector NTCC Inc.

TEL: 400-800-2947, 189-0126-8599

E-mail: biovector@163.com

http://www.biovector.net

NTCC™Murine Cytomegalovirus (MCMV) is a DNA virus belonging to the Betaherpesvirinae subfamily of the Herpesviridae family, and it is a natural pathogen of mice.

Key Characteristics

• Classification: MCMV is an enveloped, double-stranded DNA virus. Its genome structure and gene expression patterns share many similarities with human cytomegalovirus (HCMV).

• Host Specificity: MCMV has strict host specificity and can only infect mice. Although it can infect rat cells in vitro, it does not replicate in rats in vivo.

• Transmission: The virus can be transmitted through bodily fluids such as saliva, urine, and tears. In natural infections, the virus primarily establishes a persistent presence in the mouse's salivary glands.

• Clinical Symptoms: In immune-competent mice, natural MCMV infection typically does not cause obvious clinical symptoms. However, in certain mouse strains or in immune-deficient mice, it can lead to central nervous system or myocardial pathologies.

Research Applications

Because human cytomegalovirus (HCMV) has strict species specificity and cannot directly infect mice, the MCMV-mouse model has become a crucial alternative for studying HCMV-related diseases and pathogenesis. Researchers use this model to:

• Study Immune Responses: Explore the mechanisms of both innate and adaptive immune responses to cytomegalovirus infection.

• Vaccine and Antiviral Drug Development: Evaluate the efficacy of vaccine candidates and new antiviral drugs.

• Study Viral Latency and Reactivation: After infection, cytomegaloviruses enter a latent phase and can reactivate under specific conditions. The MCMV model is an ideal tool for studying this complex process.

It is important to note that while MCMV is common in wild mice, it is rare in laboratory mice. Therefore, for laboratories conducting relevant research, it is crucial to regularly perform antibody tests to ensure that experimental animals are not naturally infected.

BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心

BioVector NTCC Inc.

TEL: 400-800-2947, 189-0126-8599

E-mail: biovector@163.com

http://www.biovector.net