NTCC™变形链球菌 UA140菌株Streptococcus mutans UA140 strain BioVector NTCC典型培养物保藏中心

The NTCC™Streptococcus mutans UA140 strain is a well-characterized and widely studied bacterial strain, primarily known for its role in dental caries (tooth decay). It is a "group I" strain of S. mutans, which is a class of bacteria that are considered major contributors to tooth decay in humans.

Here are some key characteristics and research applications of the UA140 strain:

Key Characteristics

• Mutacin Production: A defining feature of the UA140 strain is its ability to produce antimicrobial substances called mutacins. Mutacins are a type of bacteriocin (antibacterial peptide) that S. mutans uses to compete with other bacteria in the oral cavity. Research has shown that UA140 produces at least two different mutacins:

  • Mutacin I: A lantibiotic, which is a class of peptide antibiotics.

  • Mutacin IV: A non-lantibiotic, two-peptide bacteriocin.

• Genetic Profile: The complete genome sequence of the UA140 strain has been determined. This allows researchers to study its specific genes and how they contribute to its virulence, survival, and mutacin production.

• Biofilm Formation: Like other S. mutans strains, UA140 is highly effective at forming biofilms (dental plaque) on tooth surfaces. This ability is a major virulence factor, as the biofilm protects the bacteria and allows them to produce high concentrations of lactic acid.

Research Applications

The UA140 strain is a valuable model organism in dental and microbiology research. It's used to study:

• Dental Caries Pathogenesis: Researchers use UA140 to understand how S. mutans colonizes the teeth, forms biofilms, and produces acid that leads to tooth enamel demineralization.

• Microbial Competition: The production of mutacins by UA140 is a key area of study to understand how this bacterium maintains its dominance in the complex oral microbiome. The ability to produce different types of mutacins gives it a competitive advantage.

• Antimicrobial Development: The mutacins produced by UA140 are being investigated as potential new antimicrobial agents to specifically target and control the populations of cariogenic bacteria in the mouth.

• Genetics and Metabolism: The complete genome data for UA140 is used to explore the genetic basis of its unique traits, such as its ability to produce specific enzymes and to tolerate the acidic and oxidative stress conditions in the oral cavity.

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NTCC™变形链球菌 UA140 菌株

NTCC™变形链球菌 UA140 菌株 (Streptococcus mutans UA140 strain) 是一种经过深入研究且广为人知的细菌菌株，主要因其在龋齿（蛀牙）形成中的作用而闻名。它属于“I群”变形链球菌，是导致人类蛀牙的主要细菌之一。

主要特点

• 产生 Mutacin (突变菌素): UA140 菌株的一个显著特征是它能产生名为突变菌素 (mutacin) 的抗菌物质。突变菌素是一种细菌素（抗菌肽），S. mutans 利用它来与口腔中的其他细菌竞争。研究表明，UA140 至少产生两种不同的突变菌素：

  • 突变菌素 I (Mutacin I): 一种羊毛硫肽，属于肽类抗生素。

  • 突变菌素 IV (Mutacin IV): 一种非羊毛硫肽类的双肽细菌素。

• 基因图谱: UA140 菌株的完整基因组序列已经被测定。这使得研究人员能够研究其特定基因，以及这些基因如何促进其毒性、生存能力和突变菌素的产生。

• 生物膜形成: 与其他_S. mutans_菌株一样，UA140 非常善于在牙齿表面形成生物膜（牙菌斑）。这种能力是一个主要的毒力因子，因为生物膜能保护细菌，并使它们能产生高浓度的乳酸。

研究应用

UA140 菌株是牙科和微生物学研究中一个重要的模式生物，被用于研究：

• 龋齿发病机制: 研究人员利用 UA140 来理解_S. mutans_如何定植于牙齿、形成生物膜并产生酸，从而导致牙釉质脱矿。

• 微生物竞争: 研究 UA140 产生的突变菌素是理解这种细菌如何维持其在复杂口腔微生物群落中主导地位的关键领域。它能产生不同类型的突变菌素，这赋予了它竞争优势。

• 抗菌药物开发: 科学家正在研究 UA140 产生的突变菌素，以期开发新的抗菌剂，专门用于靶向和控制口腔中的致龋细菌群体。

• 遗传学和代谢: UA140 的完整基因组数据被用来探索其独特特性的遗传基础，例如其产生特定酶的能力以及在口腔的酸性和氧化应激条件下生存的能力。