ROSA NTCC®小鼠胚胎成纤维细胞株mouse embryonic fibroblast cell line BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

ROSA NTCC®小鼠胚胎成纤维细胞株mouse embryonic fibroblast cell line

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

• ROSA Cells: These are a type of mouse embryonic fibroblast cell line.

• **Key Feature: "ROSA" stands for "Recombinase Organizing Sequence for Activity". These cells are genetically engineered to contain a specific DNA sequence called a "loxP" site.

• Significance in Research:

  • Conditional Gene Knockout/Knockin: The loxP site allows for the conditional manipulation of genes. By introducing a Cre recombinase enzyme (which recognizes and cuts at loxP sites), researchers can precisely delete or insert specific genes in a targeted manner. This is crucial for studying gene function in various tissues and developmental stages.

  • Gene Targeting: ROSA cells are widely used in creating genetically modified mouse models for studying human diseases.

  
  

In summary: ROSA cells are a valuable tool for genetic engineering in mice, enabling researchers to investigate gene function and model human diseases.

Note: There are different variations of ROSA cells, such as ROSA26 cells, which are commonly used for gene targeting.

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