MODE-K NTCC®小鼠十二指肠上皮细胞株mouse intestinal epithelial cell line BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

MODE-K NTCC®小鼠十二指肠上皮细胞株mouse intestinal epithelial cell line

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

The NTCC® MODE-K cell line is a valuable tool for studying intestinal epithelial cell function, particularly in the context of mucosal immunity and gluten toxicity. Here are some key aspects:

• Origin: Derived from the mouse duodenum.

• Characteristics:

  • Immortalized by the SV40-large T gene.

  • Retains key features of intestinal epithelial cells.

  • Can express MHC class II molecules upon stimulation with interferon-gamma, allowing for antigen presentation.

  
  

• Applications:

  • Mucosal Immunology: Investigating interactions between intestinal epithelial cells and immune cells.

  • Gluten Toxicity: Studying the mechanisms of gluten-induced damage in celiac disease.

  • Drug Development: Screening for compounds that modulate intestinal epithelial cell function or protect against gluten toxicity.

  
  

Key Points:

• MODE-K cells provide a valuable in vitro model for studying intestinal epithelial cell biology.

• Their ability to express MHC class II molecules makes them useful for investigating immune responses in the gut.

• Research using MODE-K cells contributes to our understanding of intestinal diseases and the development of new therapies.

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BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

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