SB-28 NTCC®小鼠胶质母细胞瘤细胞株murine (mouse) glioblastoma (GBM) cell line BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

SB-28 NTCC®小鼠胶质母细胞瘤细胞株murine (mouse) glioblastoma (GBM) cell line

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

SB-28 is a murine (mouse) glioblastoma (GBM) cell line.

Key Features

• Murine Origin: Derived from a mouse model of glioblastoma.

• Luciferase Expression: Engineered to express luciferase, which allows for non-invasive imaging of tumor growth in vivo using bioluminescence imaging techniques.

• Genetic Modifications: Contains specific genetic alterations that mimic key features of human GBM, such as mutations in genes involved in cell growth and survival.

• Research Applications

  • Glioblastoma Research: Used to study the biology of glioblastoma, including tumor growth, invasion, and response to therapies.

  • Drug Development: Used to screen for and evaluate new anti-cancer drugs for the treatment of glioblastoma.

  • Immunotherapy Research: Used to investigate the role of the immune system in glioblastoma and to develop immunotherapies for this disease.

Significance in Research

Glioblastoma is a highly aggressive and deadly brain tumor. SB-28 cell line provides a valuable preclinical model for studying this disease and developing new treatments. Its ability to express luciferase enables researchers to monitor tumor growth in real-time, which is crucial for assessing the effectiveness of different therapies.

Note

• The use of SB-28 cells requires appropriate safety measures in the laboratory, as it involves working with genetically modified organisms.

• The characteristics and behavior of SB-28 cells can be influenced by various factors, such as culture conditions and the presence of other cells or factors in the environment.

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