pLenti-CMV-LAMB3 BioVector®慢病毒LAMB3基因表达质粒 BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

pLenti-CMV-LAMB3 BioVector®慢病毒LAMB3基因表达质粒

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

BioVector® pLenti-CMV-LAMB3 is a lentiviral expression vector designed to express the LAMB3 gene.

• Lentivirus: A type of retrovirus that can efficiently infect both dividing and non-dividing cells. Lentiviral vectors are commonly used for gene delivery in various research and therapeutic applications.

• CMV Promoter: The Cytomegalovirus (CMV) promoter is a strong and widely used promoter that drives high levels of gene expression in many cell types.

• LAMB3: This gene encodes the laminin beta 3 subunit, a protein component of the extracellular matrix. Laminins are essential for cell adhesion, migration, and differentiation.

Structure of pLenti-CMV-LAMB3:

• Lentiviral Backbone: The plasmid likely contains the necessary genetic elements for lentiviral packaging, including viral genes and regulatory sequences.

• CMV Promoter: The CMV promoter drives the expression of the LAMB3 gene.

• LAMB3 Gene: The cDNA sequence encoding the LAMB3 protein is inserted downstream of the CMV promoter.

• Other Elements: The plasmid may also contain other elements such as:

  • Antibiotic Resistance Gene: Allows for selection of bacteria containing the plasmid.

  • Packaging Signals: Required for the production of lentiviral particles.

  
  

Applications of pLenti-CMV-LAMB3:

• Gene Therapy: This vector could be used to deliver the LAMB3 gene to cells that are deficient in LAMB3 expression, such as in certain genetic disorders.

• Cell Biology Research: The vector can be used to study the function of LAMB3 in various cell types and tissues.

• Disease Modeling: The vector can be used to generate cell or animal models of diseases associated with LAMB3 deficiency.

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