ST11-KL64 bla-KPC-2 NTCC®肺炎克雷伯氏菌多药耐药株Klebsiella pneumoniae BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

ST11-KL64 bla-KPC-2 NTCC®肺炎克雷伯氏菌多药耐药株Klebsiella pneumoniae

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

ST11-KL64 bla-KPC-2 refers to a specific type of Klebsiella pneumoniae bacterium that is resistant to multiple antibiotics, including carbapenems.

Here's a breakdown:

• ST11: This refers to the sequence type of the bacteria. It is determined by analyzing specific genes within the bacterial genome. ST11 is a globally disseminated and particularly concerning sequence type of K. pneumoniae due to its high resistance and virulence.

• KL64: This refers to the capsular type of the bacteria. The capsule is a protective layer that surrounds the bacterial cell and plays a role in virulence and immune evasion.

• bla-KPC-2: This gene encodes KPC-2, a type of Klebsiella pneumoniae carbapenemase. KPC-2 is an enzyme that inactivates carbapenem antibiotics, a class of drugs that are typically used to treat serious infections caused by K. pneumoniae.

Significance of ST11-KL64 bla-KPC-2:

• Antibiotic Resistance: These bacteria are resistant to multiple antibiotics, including carbapenems, which are often the last-line treatment options for serious infections. This makes infections caused by ST11-KL64 bla-KPC-2 difficult to treat and can lead to severe outcomes.

• Global Spread: ST11 is a globally disseminated clone, meaning it has spread widely across different countries and regions.

• Public Health Threat: The emergence and spread of ST11-KL64 bla-KPC-2 strains pose a significant public health threat due to their high resistance and potential for causing severe infections.

Key Points:

• ST11-KL64 bla-KPC-2 represents a serious threat due to its antibiotic resistance, virulence, and global spread.

• Infections caused by these bacteria can be difficult to treat and can have serious consequences.

• Continuous surveillance and the development of new treatment strategies are crucial to combat the spread of these resistant strains.

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