CT-2A-Luc NTCC®小鼠脑胶质瘤细胞荧光表达株mouse glioma cell line-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

CT-2A-Luc NTCC®小鼠脑胶质瘤细胞荧光表达株mouse glioma cell line-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

NTCC® CT-2A-Luc is a mouse glioma cell line that is commonly used as a model for studying brain tumors, particularly glioblastoma.It's derived from a subcutaneous, non-metastatic murine glioma and is stably transduced with a firefly luciferase-EGFP reporter.

Here are some key features of CT-2A-Luc cells:

• Luciferase Reporter: The luciferase reporter allows for non-invasive imaging of tumor growth and response to therapy.

• EGFP Reporter: The EGFP reporter enables visualization of cell distribution and migration.

• Wild-type p53:The cells retain wild-type p53, making them a relevant model for studying p53-dependent tumorigenesis.

  
  

• High-grade Glioma Characteristics: CT-2A-Luc cells exhibit features of human high-grade gliomas, including high mitotic index, nuclear polymorphism, and microvascular proliferation.

  
  

Applications of CT-2A-Luc cells:

• Drug Discovery and Development: Screening of potential anti-cancer drugs.

• Tumor Biology Research: Studying the mechanisms of tumor growth, invasion, and metastasis.

  
  

• Preclinical Model for Therapy:Evaluating the efficacy of various therapeutic approaches, such as chemotherapy, radiation therapy, and immunotherapy.

  
  

Important Considerations:

• Cell Culture Conditions: Adherence to specific culture conditions is crucial for maintaining cell viability and function.

• Ethical Considerations: The use of animal-derived cell lines raises ethical concerns, and it's important to follow ethical guidelines for animal research.

• Limitations: While CT-2A-Luc cells provide a valuable model, they may not fully recapitulate the complexity of human glioblastoma.

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