BT-474/HR NTCC®曲妥珠单抗(赫塞汀)耐药人乳腺癌细胞株Herceptin-Resistant (trastuzumab) human breast tumor cell line-BioVector NTCC Inc.
- 价 格:¥599850
- 货 号:NTCC® BT-474/HR
- 产 地:北京
- BioVector NTCC典型培养物保藏中心
- 联系人:Dr.Xu, Biovector NTCC Inc.
电话:400-800-2947 工作QQ:1843439339 (微信同号)
邮件:Biovector@163.com
手机:18901268599
地址:北京
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BT-474/HR NTCC®曲妥珠单抗(赫塞汀)耐药人乳腺癌细胞株Herceptin-Resistant (trastuzumab) human breast tumor cell line
BioVector NTCC Inc.
BT-474: The Parent Cell Line
Origin: BT-474 cells were originally derived from a breast tumor of a 60-year-old woman with invasive ductal carcinoma.
Characteristics:
Express estrogen and progesterone receptors (ER/PR positive), meaning they are sensitive to hormones.
Overexpress HER2 (human epidermal growth factor receptor 2), a protein that promotes cell growth. This makes them relevant for studying HER2-positive breast cancers.
BT-474/HR: A Resistant Variant
HR stands for Herceptin-Resistant: Herceptin (trastuzumab) is a targeted therapy that blocks HER2 and is effective in treating many HER2-positive breast cancers. However, some cancers develop resistance to Herceptin.
Development of Resistance: BT-474/HR cells were created by exposing BT-474 cells to Herceptin over a long period. This selected for cells that were able to survive and grow even in the presence of the drug.
Significance: BT-474/HR cells are crucial for studying the mechanisms of Herceptin resistance. By comparing these cells to the original BT-474 cells, researchers can identify the changes that allow the cancer cells to evade the drug's effects.
Applications in Research
Understanding drug resistance: BT-474/HR cells help scientists understand how breast cancer cells become resistant to Herceptin and other HER2-targeted therapies.
Developing new therapies: These cells can be used to test new drugs and treatment strategies that can overcome Herceptin resistance.
Personalized medicine: Research with BT-474/HR cells may contribute to developing personalized treatment approaches for patients with HER2-positive breast cancer that has become resistant to Herceptin.
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生产厂家Supplier:
BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心
E-mail:BioVector@163.com
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