首页 » GM10742 NTCC®来自Leber遗传性视神经病变患者的类淋巴母细胞株-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

GM10742 NTCC®来自Leber遗传性视神经病变患者的类淋巴母细胞株-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

  • 价  格:¥99850
  • 货  号:NTCC®-GM10742
  • 产  地:北京
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GM10742 NTCC®来自Leber遗传性视神经病变患者的类淋巴母细胞株-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心


NTCC® GM10742 is a lymphoblastoid cell line derived from a patient with Leber's hereditary optic neuropathy (LHON).This genetic disorder primarily affects vision, causing sudden vision loss, often in young adults.


Key characteristics of GM10742 cells:

  • Mitochondrial DNA mutation: Carries a specific mutation in the mitochondrial DNA, 11778G>A, which is associated with LHON.


  • Oxidative phosphorylation defects: Impaired mitochondrial function due to the mutation.

  • Model for LHON research: Useful for studying the molecular mechanisms underlying LHON and for screening potential therapeutic agents.

By studying GM10742 cells, researchers can gain valuable insights into the pathophysiology of LHON and develop strategies to prevent or treat this debilitating disease.


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Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic  Neuropathy | Scientific Reports

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