AML-VENETOCLAX维奈克拉耐药细胞株BioVector® resistant cell line BioVector NTCC质粒载体菌种细胞基因保藏中心

BioVector® NTCC® AML-VENETOCLAX维奈克拉耐药细胞株BioVector®  resistant cell line

Venetoclax is a BH3 mimetic small molecule drug that binds and antagonises the pro-survival protein Bcl-2. Venetoclax has transformed the front-line treatment of elderly unfit AML patients.

Overexpression of anti-apoptotic proteins of the B-cell lymphoma 2 (BCL-2) family, including BCL-2, BCL-extra large (XL), and myeloid cell leukemia-1 (MCL-1), is one of the primary mechanisms hematologic cancers employ to escape cell death signaling. 1 Venetoclax (ABT-199) is a compound that selectively inhibits BCL-2, thereby mimicking the function of BH3-only proteins

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