MELK激酶稳定表达细胞株NTCC® Kinase Stable Cell Line-MELK药物靶点-BioVector NTCC细胞库

Cell Line Name：NTCC® MELK Kinase Stable Cell Line激酶稳定表达细胞株

Target药物靶点：MELK
Cat#货号:NTCC®-I-MELK
Size/Quantity数量: 1 Flask / 2 Vials
Biosafety Level生物安全级别: 1
Shipping Info运输方式: RT/Dry Ice
Storage储存方式: RT/Liquid Nitrogen
Application用途:Screening & Activity Analysis
Kinases play a central role in cell signaling to elicit many physiological responses. Dysregulation of kinase activity leads to many human diseases, especially cancer. A typical signaling pathway involves a kinase cascade to produce a cellular response starting with receptor activation via a ligand-induced activation step. Receptor-specific ligands, such as growth factors, result in receptor tyrosine kinases (RTK) dimerization or oligomerization. This often results in the receptors’ activation and autophosphorylation, allowing them to recruit and activate downstream mediators via their SH2 domains. This event then triggers a signaling cascade that leads to the phosphorylation and activation of downstream kinases to act upon various downstream target molecules, including several cytoplasmic targets and transcriptional factors. The activated targets elicit cellular responses that include the promotion of cell growth and division, protein translation, or other physiological responses. Product Highlights Comprehensive Portfolio – Binding and functional, cell-based assays for receptor dimerization, SH2 recruitment, and target engagement as well as over 420 kinases active, mutant, and inactive recombinant kinases for activity and biophysical testing Highly Applicable – Ideal for the development of small molecule and biologic therapeutics, from target ID through pre-clinical drug development programs, into therapeutic commercial release Clinically Relevant, Cell-Based Assays – Leverage and implement any of the NTCC® qualified or target-based bioassays to accelerate your biological candidate, whether it is a novel therapeutic or a biosimilar Rigorously Tested Kinase Enzymes – Kinase enzymes utilized in NTCC®KinaseProfiler services for screening millions of compounds over the past 30 years 激酶(kinase)是一类从高能供体分子（如ATP）转移磷酸基团到特定靶分子（底物）的酶；这一过程谓之磷酸化。许多肿瘤的发生是由某些与生长相关的“激酶"发生突变导致异常活化引起的，因而针对这些突变激酶的抑制剂能够有效抑制这些激酶的活性，从而达到抑制癌细胞增长的目的。
Cell Line:
EXpress Kit:
Bioassay Kit生物检测试剂盒:
Protein蛋白: 
Cell Type细胞类型: Kinase Stable Cell Line
Source组织来源:
Specification规格:
Cell Images细胞图片:
Complete Growth Medium完全培养基: NTCC® MELK Stable Cells Complete Medium
Subculturing传代方法:
Cryopreservation冻存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: RT/Liquid nitrogen vapor phase
Culture Conditions培养条件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鉴定数据:
References参考文献:

Supplier供应商:
BioVector质粒载体菌株细胞蛋白抗体基因保藏中心
NTCC典型培养物保藏中心
Tel电话：400-800-2947
Email：Biovector@163.com
http://www.biovector.net