AG09908家族性 4 型阿尔茨海默病 |早老素2; PSEN2 皮肤、手臂成纤维细胞Cell Line细胞株-BioVector NTCC细胞库

Name细胞名称：NTCC® AG09908 ALZHEIMER DISEASE, FAMILIAL, TYPE 4 | PRESENILIN 2; PSEN2 Skin, Arm Cell Line
家族性 4 型阿尔茨海默病 |早老素2; PSEN2细胞株
Description描述：The donor (Volga German) exhibited progressive dementia. Donor's paternal grandfather, aunt, two cousins and two siblings were affected with Alzheimer disease. The culture was initiated on 4/06/84 using explants of minced skin tissue taken post-mortem from the mesial aspect of the upper arm. The cell morphology is fibroblast-like. The karyotype is 46,XX; normal diploid female with 8% of the cells examined showing random chromosome loss. Culture was frozen at passage 10 and the PDL is not known. The affected sister of this donor is AG09907. A heterozygous substitution (A>T at nucleotide 787) in the AD4 [presenilin 2 (PSEN2)] gene results in an Asn141Ile (N141I) missense mutation. The legacy karyotype description shown in this Remark may not be representative of the current available product.
Category分类：Fibroblast
ID编号:NTCC®-AG09908
Size/Quantity数量: 1 Flask/2 Vials
Biosafety Level生物安全级别:1
Shipping Info运输方式: RT/Dry Ice
Storage储存方式: RT/Liquid Nitrogen
Race: White
Age年龄:81 YR
Gender性别:Female
Cell Type细胞类型: ALZHEIMER DISEASE, FAMILIAL, TYPE 4 | PRESENILIN 2; PSEN2
Affected State:Yes
Product:Fibroblast
Gene:PSEN2
Mutations突变:ASN141ILE
Ethnicity:GERMAN
Family:1138
Relationship:proband
Karyotype:
Tissue Type组织来源:Skin
Complete Growth Medium完全培养基: BioVector® Eagles Minimum Essential Medium with Earle's salts:Dulbecco's modified MEM with 2mM L-glutamine or equivalent Complete Medium
Subculturing传代方法:
Cryopreservation冻存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: liquid nitrogen vapor phase
Culture Conditions培养条件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鉴定数据:
References参考文献:

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