AG06840 ALZHEIMER DISEASE, FAMILIAL, TYPE 3 | PRESENILIN 1; PSEN1 Skin, Arm Cell Line NTCC®细胞株-BioVector NTCC细胞库

Name细胞名称：NTCC® AG06840 ALZHEIMER DISEASE, FAMILIAL, TYPE 3 | PRESENILIN 1; PSEN1 Skin, Arm Cell Line
家族性 3 型阿尔茨海默病 |早老素1; PSEN1细胞株
Description描述：The donor at time of biopsy was oriented only to the year, had poor recent memory, was unable to do simple subtraction, and had regressive reflexes. He admitted to 6 months of increasing difficulty with memory, although a previous neuro exam at age 52 revealed problems with recent memory. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 05/4/83 using explants of minced skin. The cell morphology is fibroblast-like. The culture is a mosaic with karyotype: 46,XY/46,XY, t(2;14)(2qter>2p11.2::14p11.2>14pter;14qter>14p11.2::2p11.2>2pter); balanced; 90%/10%. Culture was frozen at PDL 11. A lymphoblast culture with a 46,XY karotype from this same donor is AG06841A. Cells carry missense mutation {Ala246Glu (A246E)} in the AD3 [presenilin 1 (PSEN1)] gene. The legacy karyotype description shown in this Remark may not be representative of the current available product.
Category分类：Fibroblast
ID编号:NTCC®-AG06840
Size/Quantity数量: 1 Flask/2 Vials
Biosafety Level生物安全级别:1
Shipping Info运输方式: RT/Dry Ice
Storage储存方式: RT/Liquid Nitrogen
Race: White
Age年龄:56 YR
Gender性别:Male
Cell Type细胞类型: ALZHEIMER DISEASE, FAMILIAL, TYPE 3 | PRESENILIN 1; PSEN1
Affected State:Yes
Product:Fibroblast
Gene:PSEN1
Mutations突变:ALA246GLU
Ethnicity:CANADIAN
Family:964
Relationship:VII-13
Karyotype:
Tissue Type组织来源:Skin
Complete Growth Medium完全培养基: BioVector® Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent Complete Medium
Subculturing传代方法:
Cryopreservation冻存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: liquid nitrogen vapor phase
Culture Conditions培养条件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鉴定数据:
References参考文献:

Supplier供应商:BioVector质粒载体菌株细胞蛋白抗体基因保藏中心
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