U1/HIV-1 cell line细胞株U1 BioVector NTCC质粒载体菌种细胞基因保藏中心

U1/HIV-1 cell line细胞株U1

Cell line nameU1
SynonymsU1/HIV-1
AccessionNTCC®_M769
Resource Identification InitiativeTo cite this cell line use: U1/HIV-1 (NTCC®_M769)
CommentsPopulation: Caucasian.
Virology: Latently infected with HIV-1 isolate NY5. The two main sites of integrations are in chromosome 2 and chromosome X (PubMed=28086908).
Doubling time: 36 hours (HIVReagentProgram=ARP-165).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations•Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
•Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
•Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
•Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
•Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
DiseaseAdult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: NTCC®_0007 (U-937)
Sex of cellMale
Age at sampling37Y
CategoryCancer cell line

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