NTCC® NA20390 LCL DNA-BioVector NTCC典型培养物保藏中心Coriell NA20390

Name：NTCC® NA20390 LCL DNA
Category分类：DNA
Cat#货号:NTCC®-Coriell NA20390
Size/Quantity数量: 1 Vial
Biosafety Level生物安全级别:1
Shipping Info运输方式: RT
Storage储存方式: 4C
Species物种来源:
Age年龄: 4 YR
Gender性别: Female
Description描述: ACUTE LYMPHOCYTIC LEUKEMIA | TRANSLOCATED CHROMOSOME
Remarks: Clinically affected with pre-B acute lymphoblastic leukemia; donor subject suffered from general fatigue and anemia at age 3 years; bone-marrow examination at age 3 years showed 99% of blasts with French-American-British L1 morphology and pre-B-cell phenotype carrying a t(1;19)(q23;p13) translocation; early bone-marrow relapse occurred despite aggressive multidrug-combined chemotherapy; donor subject died from a fungal infection less than one year after diagnosis; cell line established from donor subject's peripheral blood at relapse; cells had basophilic cytoplasm with prominent vacuoles and oval nuclei with one or more prominent nuceoli; cells were negative for peroxidase, PAS, alpha-naphthyl butyrate esterase, and naphthol ASD chloroacetate esterase activities; cells expressed CD19, CD22, HLA-DR, and CD34 antigens but were negative for CD3, CD4, CD8, CD10, CD20, CD33, and surface immunoglobulins; cells harbored cIg and a rearranged Ig heavy-chain gene; cell line had neither E2A rearrangement nor PBX1 expression; cell line had no E2A/PBX1 chimeric transcripts; cloned breakpoints of cell line fell within introns of MEF2D and DAZAP1; the chimeric transcripts MEF2D-DAZAP1 and DAZAP1-MEF2D, whose sequences indicated in-frame fusions between MEF2D and DAZAP1, were expressed in the cell line and in bone-marrow cells from the donor subject.
Alternate IDs其他编号:
Cell Type细胞类型: LCL
Source组织来源: LCL
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Supplier供应商:
BioVector质粒载体菌株细胞蛋白抗体基因保藏中心
NTCC典型培养物保藏中心
Tel电话：400-800-2947
Email：Biovector@163.com
http://www.biovector.net