NTCC® NA23245 Tumor-derived cell line DNA-BioVector NTCC典型培养物保藏中心Coriell NA23245

Name：NTCC® NA23245 Tumor-derived cell line DNA
Category分类：DNA
Cat#货号:NTCC®-Coriell NA23245
Size/Quantity数量: 1 Vial
Biosafety Level生物安全级别:1
Shipping Info运输方式: RT
Storage储存方式: 4C
Species物种来源:
Age年龄: 59 YR
Gender性别: Female
Description描述: THROMBOCYTHEMIA, ESSENTIAL | LEUKEMIA, ACUTE MYELOID; AML | JANUS KINASE 2; JAK2
Remarks: Line UKE-1; at age 30 years subject developed carcinoma of the cervix and was treated surgically; 17 years later at age 47 she was diagnosed with essential thrombocythemia controlled with hydroxyurea without bleeding or thrombotic episodes; at age 59 she had pain and swelling of the right shoulder; exam revealed 5cm right supraclavicular mass and enlarged cervical and axillary lymph nodes; histologic exam was consistent with an epitheloid angiosarcoma of UICC grade 2; six cycles of ifosfamide and adriblastin were administerd; six months later patient presented with multiple skin infiltrations and bilateral pleural effusions; bone marrow biopsy showed infiltration with 54% blast cells; essential thrombocythemia appeared to have transformed into acute myelogenous leukemia; chemotherapy with cytosine arabinoside and mitoxanthrone did not result in regression and the patient died; this culture was derived from primary leukemic cells obtained from the patient's peripheral blood; this line appears to combine hematopoietic and endothelial features indicating the close ontogenic relation of both lineages; this donor was heterozygous for a G>T transversion in the JAK2 gene resulting in the substitution of phenylalanine for valine at codon 617 [Val617Phe (V617F)]; the cell line is homozygous for the JAK2 mutation.
Alternate IDs其他编号:
Cell Type细胞类型: Tumor-derived cell line
Source组织来源: Tumor-derived cell line
Gene: JAK2
Disease疾病类型:
Mutations突变: VAL617PHE
Karyotypes核型:
Cytogenetics:
Mutation description突变描述:
Origin:
Transformants:
Alias别名:
Images图片:
References参考文献:

Supplier供应商:
BioVector质粒载体菌株细胞蛋白抗体基因保藏中心
NTCC典型培养物保藏中心
Tel电话：400-800-2947
Email：Biovector@163.com
http://www.biovector.net