HKE-3 cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

HKE-3 cell line细胞株

Cell line name NTCC® HKe-3
Synonyms HKE-3; Hke-3; HKE3; Hke3
Accession NTCC®_9796
Resource Identification Initiative To cite this cell line use: HKe-3 (NTCC®_9796)
Comments Characteristics: In HCT 116 one of the two KRAS alleles has a p.Gly13Asp mutation. This cell line is KO for the mutant allele.
Knockout cell: Method=Homologous recombination (1 of 2 alleles); HGNC; 6407; KRAS.
Omics: Transcriptome analysis by RNAseq.
Derived from sampling site: Colon.
Sequence variations
Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: NTCC®_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line

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