HIV潜伏感染细胞模型cell model BioVector NTCC质粒载体菌种细胞基因保藏中心

HIV潜伏感染细胞模型cell model

Recent progress in primary cell models of HIV latency has facilitated research on the mechanisms of HIV latency. HIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. A model that utilizes cultured central memory CD4+ T cells and replication-competent HIV-1. It has been challenging to develop a primary cell model of HIV latency that can authentically recapitulate the quiescent features of resting CD4+ T cells. Recently, several articles have described different approaches that can generate latently HIV-infected resting CD4+ T cells in vitro. Some of them further demonstrated that the primary cell models of HIV latency are suitable for biochemical studies and drug screening. Summary: Recent progress in primary cell models of HIV latency has facilitated research on the mechanisms of HIV latency. These models also serve as a platform for the discovery of drugs that can purge the latent reservoir for HIV in resting CD4+ T cells. These studies will allow deeper insight to the mechanisms governing HIV latency and may help identify some candidate compounds for use in therapeutic strategies for the eradication of latent HIV.

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