pcDNA3-E2F3 gene基因表达质粒敲除编辑载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3-E2F3 gene基因表达质粒敲除编辑载体

BioVector® pcDNA3-E2F3 plasmid

E2F3 gene
RefSeq NM_001949.5
RefSeq Size 4744 bp
RefSeq ORF 1398 bp
Locus ID 1871
Domains E2F_TDP
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer
MW 49 kDa
Gene Summary This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants.

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