BV-2 Mouse Microglial Cell Line永生化小鼠小胶质细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

BV-2 Mouse Microglial Cell Line永生化小鼠小胶质细胞株

BV-2 Cells Derivation and biomarker
NTCC® BV-2 is a type of microglial cell derived from C57/BL6 murine. The NTCC® BV2 cells are immortalized by v-raf/v-myc carrying J2 retrovirus. NTCC® BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level. NTCC® BV2 microglia cell line retains microglia morphological and functional characteristics. In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in vitro NTCC® BV-2 greatly exceeds that of other microglia.

NTCC® BV-2 cells are positive for MAC1 and MAC2 antigens, negative for MAC3, glial fibrillary acidic protein (GFAP) and galactocerebroside (GC).

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Growth Properties
Microglial

BV-2 Cells Application and example model
In the central nervous systems (CNS), microglial cells are resident macrophages. NTCC® BV-2 shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. Like other microglia, BV-2 can be activated to release pro-inflammatory cytokines by oxidative stress or inflammatory factors. Such stimulus possibly triggers neurodegenerative disorder such as Alzheimer and Parkinson disease, thus NTCC® BV-2 is widely used as an alternative model system for primary microglia and neurodegenerative disease model in vitro. The model is usually induced by Lipopolysaccharide (LPS) treatment.

Product Type
Mouse Brain Cancer Cell Lines

MEM + 10% Foetal Bovine Serum (FBS) + 100 U/ml penicillin G sodium (option); 100 µg/ml streptomycin sulfate (option);

Supplier来源:BioVector NTCC Inc.
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