MDA-MB-231br cell line人胸膜腔积液乳腺腺癌脑转移细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

MDA-MB-231br cell line人胸膜腔积液乳腺腺癌脑转移细胞株

Cell line name MDA-MB-231br
Synonyms MDA-231BR

Comments
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to brain. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the brain metastatic cells and repeating this procedure 6 times.

Sequence variations
Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).

Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Children:
(MDA-MB-231br/eGFP )

Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

Supplier来源:BioVector NTCC Inc.
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