pcDNA-KDM6b-Neo基因表达质粒载体pcDNA3-JMJD3; NEDCFSA BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA-KDM6b-Neo基因表达质粒载体pcDNA3-JMJD3; NEDCFSA

BioVector's pcDNA-KDM6b-Neo plasmid expresses Human lysine (K)-specific demethylase 6B (KDM6B).
RefSeq NM_001080424.2
RefSeq Size 6704 bp
RefSeq ORF 5049 bp
Locus ID 23135
MW 180.5 kDa
Gene Summary The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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