Human ACE2 & TMPRSS2a Expression Vector Human ACE2 and TMPRSS2a genes质粒载体-BioVector质粒保藏中心

Name质粒名称:Human ACE2 & TMPRSS2a Expression Vector Human ACE2 and TMPRSS2a genes
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Description描述:SARS-CoV-2-Cellular Receptor Genes cell surface receptors InvivoGen also offersINVIVOGEN ALSO OFFERS: • SARS-CoV-2-Structural Genes ACE2 & TMPRSS2 Human ACE2 (angiotensin I-converting enzyme-2) and TMPRSS2 (transmembrane protease serine 2) are two surface membrane receptors that are involved in SARS-CoV-2 (or 2019-nCoV) entry into host target cells [1-3]. Virus docking to the cells occurs upon binding of the viral Spike protein to ACE2. The virus can then use either endocytosis or fusion with the surface membrane to enter the cells. In both cases, ACE2-bound Spike must be cleaved ("activated") by specific proteases to allow the Spike fusion domains to operate. In the endosomes, Spike is cleaved by Cathepsin L, then the viral membrane fuses with the endocytic membrane. At the cell surface, Spike is cleaved by other proteases, mainly TMPRSS2, to ensure virus and host-cell membrane fusion [1-3]. After the fusion, SARS-CoV-2 genomic and protein content is delivered into the cytosol, and the virus starts its replication cycle.
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