CHO-K1/TIGIT cell line稳转细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥998685
- 货 号：CHO-K1/TIGIT
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作QQ:1843439339 (微信同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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CHO-K1/TIGIT cell line稳转细胞株
DescriptionTIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.SynonymsWUCAM, Vstm3Species humanFreeze Medium 95% complete growth medium, 5% DMSOCulture Medium F12K, 10% FBS, 6 μg/ml PuromycinProperties Stability 15 passagesStorage Liquid nitrogen immediately upon receivingApplications Binding assays or use as immunogen
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
DescriptionTIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.SynonymsWUCAM, Vstm3Species humanFreeze Medium 95% complete growth medium, 5% DMSOCulture Medium F12K, 10% FBS, 6 μg/ml PuromycinProperties Stability 15 passagesStorage Liquid nitrogen immediately upon receivingApplications Binding assays or use as immunogen
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
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