IMCE cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

IMCE cell line细胞株

The colonic epithelium of the multiple intestinal neoplasia (MIN) mouse [Immortomouse × MIN colonic epithelium (IMCE) carries one mutant Apc allele.
The IMCE cell line has proved to be useful for studying malignant progression because, although the IMCE cell line is phenotypically normal, it has proven to be susceptible to transformation. Transfection of the cells with an activated Ras gene or an activated β-catenin gene induced a malignant transformation in these cells but not in the parental Immortomouse (YAMC) cell line. In a recent review, this pair of cell lines was described as the best model system available for studying malignant progression in colon cancer.

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