LOX-IMVI Human Melanoma Cell Line人黑色素瘤细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

LOX-IMVI Human Melanoma Cell Line人黑色素瘤细胞株

Malignant melanoma is highly treatable when diagnosed early, but can spread rapidly if undetected, resulting in the highest mortality among skin cancer types. Lymph nodes and lungs are the most common sites of melanoma metastases [4], and because of the poor prognosis and limited efficacy of current treatments, metastatic melanoma has generated intense interest as a target for therapeutic intervention.The LOX-IMVI human melanoma cell line is widely used as an in vitro model system to study tumor metastasis and to test for chemosensitivity to potential anti-cancer compounds. LOX-IMVI cells exhibit a tendency to form lung metastases in nude mice independent of the inoculation site [2], and mortality of experimental animals is observed within 3-5 weeks of LOX-IMVI cell injection [3]. LOX-IMVI cells are genetically characterized by lack of the Y chromosome and trisomy 7 [2], and are heterozygous for the BRAF V600E melanoma driver mutation [5]. LOX-IMVI cells are amelanotic and express the human melanoma marker GD3 ganglioside, a factor in metastatic potential of malignant melanoma [1].Source:The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma [2].Cell Line DescriptionCancer CellsApplicationLOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.Research CategoryCancer

Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net