Staphylococcus aureus - Xen40 strain生物发光金黄色葡萄球菌菌株 BioVector NTCC质粒载体菌种细胞基因保藏中心

Staphylococcus aureus - Xen40 strain生物发光金黄色葡萄球菌菌株

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.Engineered Bacterium: Staphylococcus aureus - Xen40Parental Strain: UAMS-1In Vitro/Ex Vivo: Growth profiles, Catheter modelIn Vivo: BiofilmAdvantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well formatSensitivity - subtle changes in cellular viability are rapidly detectedInexpensive - no additional substrates needed for bacterial assaysAdvantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:Rapid identification of lead drug candidatesReal-time efficacy dataMay help to decrease drug failure by allowing disease relapse to be monitored in the same animal

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