HECTD1 gene plasmid表达质粒沉默干扰载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

HECTD1 (HECT Domain E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with HECTD1 include Spastic Paraplegia 32, Autosomal Recessive and Prostate Small Cell Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is HECTD4.

UniProtKB/Swiss-Prot Summary for HECTD1 Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. HECD1_HUMAN,Q9ULT8
Additional gene information for HECTD1 Gene

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