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人正常口腔组织细胞系HOK
Cell Specification
Oral keratinocytes act as the major barrier to physical, microbial, and chemical agents that may
cause local cell injury. They are involved in the proinflammatory process through the production of
cytokines either constitutively or after a variety of stimuli [1]. Consequently, oral keratinocytes
may potentially participate in controlling oral infections through an inflammatory process involving
different interleukins, such as IL-1ß and IL-18 [2]. Oral keratinocytes express a variety of
differentiation markers, the expression of which is influenced by calcium-induced changes in the
transcription of target genes [3]. Oral keratinocytes share major structural and functional features
with the well-characterized dermal keratinocyte and are a good model to study basic keratinocyte
biology, as well as, processes of immortalization and malignant transformation.
HOK are isolated from human oral mucosa. HOK are
cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105cells in 1 ml
volume. HOK are characterized by immunofluorescence with antibodies specific to cytokeratin-8, -
18 and/or -19. HOK are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi.
HOK are guaranteed to further expand for 10 population doublings under the conditions provided
by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Oral Keratinocyte Medium (OKM, Cat. #2611) for the culturing of HOK
in vitro.
Product Use
HOK are for research use only. They are not approved for human or animal use, or for application
in in vitro diagnostic procedures.
References
[1] Lundqvist C, Baranov V, Teglund S, Hammarstrom S, Hammarstrom ML. (1994) “Cytokine profile and
ultrastructure of intraepithelial gamma delta T cells in chronically inflamed human gingiva suggest a cytotoxic effector
function.” J. Immunol. 153:2302-2312.
[2] Rouabhia M, Ross G, Page N, Chakir J. (2002) “Interleukin-18 and Gamma Interferon Production by Oral Epithelial
Cells in Response to Exposure to Candida albicans or Lipopolysaccharide Stimulation.” Infect. Immun. 70:7073-7080.
[3] Presland RB, Dale BA. (2000) “Epithelial structural proteins of the skin and oral cavity: function in health and
disease.” Crit. Rev. Oral Biol. Med. 11:383-408.
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