pcDNA3.1-MASP1，MAP44基因表达质粒敲除载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-MASP1，MAP44基因表达质粒敲除载体

RefSeq NM_001031849.1, NP_001027019.1 RefSeq Size 2072 bp RefSeq ORF 1143 bp Locus ID 5648 Cytogenetics 3q27.3 Protein Families Druggable Genome, Protease Protein Pathways Complement and coagulation cascades MW 43.5 kDa Gene Summary This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

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