pcDNA3.1-MASP2基因表达质粒敲除载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-MASP2基因表达质粒敲除载体

RefSeq NM_006610.1, NM_006610.2, NM_006610.3, NP_006601.2 RefSeq Size 2460 bp RefSeq ORF 2061 bp Locus ID 10747 Cytogenetics 1p36.22 Domains CCP, CUB, Tryp_SPc, EGF_CA, EGF Protein Families Druggable Genome, Protease, Secreted Protein Protein Pathways Complement and coagulation cascades MW 75.69 kDa Gene Summary This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed

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