ACE2 polyclonal antibody新型冠状病毒受体ACE2多克隆抗体

Product Name ACE2 polyclonal antibody
Applications WB ICC IHC IP
Alternative Name ACEH, ACE2, ACE 2, ACE related carboxypeptidase, ACE-related carboxypeptidase, ACE2, ACE2, ACEH, Angiotensin converting enzyme 2, Angiotensin converting enzyme homolog, Angiotensin converting enzyme like protein, Angiotensin I Converting Enzyme (peptidyl
Swiss-Prot Q9BYF1(Human) Q8R0I0(Mouse) Q5EGZ1(Rat)
Host Rabbit
Reactivity Human, Mouse, Rat
Application_all WB:1:1,000-1:5,000 ICC:1:100-1:500 IHC:1:50-1:200
Product Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity ProA affinity purified
Storage&Stability Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity ACE2 polyclonal antibody detects endogenous levels of ACE2 protein.
BiowMW 92 kDa
Note For research use only, not for use in diagnostic procedure.
Immunogen recombinant protein

Western blot analysis of ACE2 on human kidney lysates using anti-ACE2 antibody at 1/1,000 dilution.

ICC staining ACE2 in 293 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Background

Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.

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