MCF-7/TAM cell line人乳腺癌细胞MCF-7他莫昔芬（Tamoxifen,TAM）耐药细胞株细胞系 BioVector NTCC质粒载体菌种细胞基因保藏中心

MCF-7/TAM cell line人乳腺癌细胞MCF-7他莫昔芬（Tamoxifen,TAM）耐药细胞株细胞系 BioVector NTCC质粒载体菌种细胞基因保藏中心
Background information
Estrogen receptor-positive breast cancer is the most common type of breast cancer. About 80% of all breast cancers express the estrogen receptor (ER+) and depend on estrogen to support the growth and spread of the cancer cells. Hormonal therapy, such as tamoxifen, may help slow or stop the growth of ER+ breast cancers by blocking the actions of estrogen. Primary or acquired tamoxifen resistance poses a major clinical challenge in the treatment of ER+ breast cancer. The MCF-7/TAMR-1 cell line provides a model cell system for studying tamoxifen resistance, elucidating signaling pathways involved in tamoxifen-resistant growth, and identifying new predictive markers for response to hormonal therapy.

MCF-7/TAMR-1 is a tamoxifen-resistant cell line derived from the MCF-7/SO.5 cell line that has been adapted to grow at low serum concentration under the long-term treatment with 1 µM with tamoxifen. MCF-7/TAMR-1 cells should be maintained in 1 µM tamoxifen and may be compared with the parental MCF-7/S0.5 cells, which are sensitive to tamoxifen.

References:
1. Briand, P., and Lykkesfeldt, A.E. (1984) Effect of estrogen and antiestrogen on the human breast cancer cell line MCF-7 adapted to growth at low serum concentrations. Cancer Res. 44(3): 1114-1119.
2. Lykkesfeldt, A.E., and Briand, P. (1986) Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines. Br. J. Cancer 53(1): 29-35.
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