HPDE6-C7人正常胰腺导管上皮细胞 BioVector NTCC质粒载体菌种细胞基因保藏中心

HPDE6-C7人正常胰腺导管上皮细胞 BioVector NTCC质粒载体菌种细胞基因保藏中心
Cell line name HPDE6c7
Synonyms H6c7; H6C7
Comments Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16) [E6/E7 (pLXSN)].
Omics: Proteome analysis by 2D-DE/MS.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: (HPDE-6/E6E7)
Sex of cell Female
Category Transformed cell line

HPDE6c7 is an immortalized epithelial cell line derived from normal human pancreatic duct epithelial (HPDE) cells. This cell line is an attractive model for human pancreatic duct cell carcinogenesis studies.

Highlights
• Demonstrate near normal genotype and phenotype of HPDE cells
• Display copy number of p16INK4A gene, wild type p53 and KRAS genes
• Morphologically similar to the primary HPDE cells, grow anchorage-dependently and do not form tumors in scid mice
• Growth remains inhibited by transforming growth factor (TGF)-beta 1

Publications
PubMed=11073822; DOI=10.1016/S0002-9440(10)64800-6
Ouyang H., Mou L.-J., Luk C., Liu N., Karaskova J., Squire J.A., Tsao M.-S.
Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype.
Am. J. Pathol. 157:1623-1631(2000)

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