NPC1L1-EGFP荧光过表达质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心

NPC1L1-EGFP荧光过表达质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心 NPC1L1-EGFP荧光过表达质粒，表达Human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1).
RefSeq: NM_001101648.1, NP_001095118 RefSeq Size: 4985 RefSeq ORF: 3999 Synonyms : NPC11L1; NPC11L1 LocusID: 29881 Cytogenetic: 7p13 Summary: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心
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