mHypoE-42 NTCC®永生化小鼠下丘脑神经元细胞株immortalized mouse hypothalamic neurons cell line-BioVector NTCC细胞保藏中心

mHypoE-42 NTCC®永生化小鼠下丘脑神经元细胞株immortalized mouse hypothalamic neurons cell line-BioVector NTCC细胞保藏中心

This is for informational purposes only. For medical advice or diagnosis, consult a professional.

The NTCC® mHypoE-42 cell line is a line of immortalized mouse hypothalamic neurons that secrete neuropeptide Y (NPY). NPY is a neurotransmitter that plays a role in regulating appetite, energy expenditure, and reproduction. The mHypoE-42 cell line is a valuable tool for studying the role of NPY in these processes.

The mHypoE-42 cell line was originally derived from the hypothalamus of a 14-day-old mouse embryo. The cells were immortalized by transfection with a retrovirus containing the SV40 large T antigen. The mHypoE-42 cell line has been used in a variety of studies to investigate the role of NPY in the regulation of appetite, energy expenditure, and reproduction.

Here are some of the key findings that have been made using the mHypoE-42 cell line:

• NPY is a potent stimulator of food intake.

• NPY increases energy expenditure.

• NPY inhibits the release of GnRH, which is a hormone that stimulates the release of LH and FSH. LH and FSH are hormones that are essential for reproduction.

• Kisspeptin, a peptide that is released by the arcuate nucleus of the hypothalamus, stimulates the release of NPY from the mHypoE-42 cell line.

The mHypoE-42 cell line is a valuable tool for studying the role of NPY in the regulation of appetite, energy expenditure, and reproduction. It is a relatively simple and inexpensive system to use, and it has been shown to be a reliable model for studying the effects of NPY on these processes.

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