Amyloid Precursor Protein APP基因表达质粒敲除载体 BioVector NTCC质粒载体菌种细胞基因保藏中心
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Amyloid Precursor Protein APP基因表达质粒敲除载体
Product Name Amyloid Precursor Protein (APP) (NM_001136129) Human Tagged ORF Clone
Symbol APP
Synonyms AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4
ACCN NM_001136129
ORF Size 1917 bp
RefSeq NM_001136129.1, NM_001136129.2, NP_001129601.1
RefSeq ORF 1920
Locus ID 351
Cytogenetics 21q21.3
Protein Families Druggable Genome, Transmembrane
Protein Pathways Alzheimer's disease
MW 72.55 kDa
Gene Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene
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